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Dominika Bąk, David Aebisher and Dorota Bartusik-AebisherMedical College of The University of Rzeszów, Rzeszów, PolandPart of the book: The Biochemical Guide to EnzymesAbstractCancer is the leading cause of death in the world, with nearly 10 million people dying from cancer each year. As a result, for many years, doctors, pharmacists and biochemists from around the world have been working intensively on more and more effective therapies in the treatment of neoplastic diseases.Keywords: pyruvate dehydrogenase, citric acid, Krebs cycleReferencesFeng Y, Xiong Y, Qiao T, Li X, Jia L, Han Y. Lactate dehydrogenase A: A key player incarcinogenesis and potential target in cancer therapy.Cancer Med. 2018 Dec;7(12): 6124-6136.Ferrarini MG, Nisimura LM, Girard RMBM, Alencar MB, Fragoso MSI, Araújo-Silva CA,Veiga AA, Abud APR, Nardelli SC, Vommaro RC, Silber AM, France-Sagot M, ÁvilaAR. Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases asTargets Worth Investigating for Effective Therapy of Toxoplasmosis.mSphere. 2021 Jan 6;6(1):e01002-20.Han Y, Sun W, Ren D, Zhang J, He Z, Fedorova J, Sun X, Han F, Li J. SIRT1 agonismmodulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase duringischemia and reperfusion. Redox Biol. 2020 Jul;34:101538.Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, RiceCM, Rouault TA, Cassel T, Higashi RM, Lane AN, Fan TW, Wink DA, McVicar DW.Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targetingaconitase 2 and pyruvate dehydrogenase. Nat. Commun. 2020 Feb 4;11(1):698.Stacpoole PW. Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/PyruvateDehydrogenase Kinase (PDC/PDK) Axis in Cancer. J. Natl. Cancer Inst. 2017 Nov 1;109(11).
