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Maria Słobodzian, David Aebisher and Dorota Bartusik-AebisherMedical College of The University of Rzeszów, PolandPart of the book: The Biochemical Guide to EnzymesAbstractCholine acetyltransferase (ChAT) is an enzyme produced in the central nervous system. This protein is synthesized in the body of cholinergic nerve cells, from where it is then transported to the axonal endings. Most probably, this transport takes place on a fast and slow road.Keywords: choline acetyltransferase, renal terminals, enzymes, biochemistryReferencesAbicht A, Müller JS, Lochmüller H. Congenital Myasthenic Syndromes Overview. 2003May 9 [updated 2021 Dec 23]. In: Adam MP, Ardinger H H, Pagon R A, Wallace SE, Bean L J H, Gripp K W, Mirzaa G M, Amemiya A, editors. GeneReviews®[Internet]. Seattle (WA): University of Washington, Seattle; 1993–2021. PMID:20301347.Cox M A, Duncan G S, Lin G H Y, Steinberg B E, Yu L X, Brenner D, Buckler L N, EliaA J, Wakeham A C, Nieman B, Dominguez-Brauer C, Elford A R, Gill K T, Kubli SP, Haight J, Berger T, Ohashi P S, Tracey K J, Olofsson P S, Mak T W. Cholineacetyltransferase-expressing T cells are required to control chronic viral infection.Science. 2019 Feb 8;363(6427):639-644.Han B, Li X, Hao J. The cholinergic anti-inflammatory pathway: An innovative treatmentstrategy for neurological diseases. Neurosci. Biobehav. Rev. 2017 Jun;77:358-368.Toan N K, Tai N C, Kim S A, Ahn S G. Choline Acetyltransferase Induces the FunctionalRegeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice. Int. J. Mol. Sci.2021 Jan 2;22(1):404.Zhang X, Lei B, Yuan Y, Zhang L, Hu L, Jin S, Kang B, Liao X, Sun W, Xu F, Zhong Y,Hu J, Qi H. Brain control of humoral immune responses amenable to behaviouralmodulation. Nature. 2020 May;581(7807):204-208.
